When Beatrice Hemmings learns that her younger sister has gone missing in London, she hurriedly returns to her home country to comfort and assist her mother and the investigation. Tess is found one week later in circumstances that suggest suicide. Beatrice is unbelieving and so begins her search for the truth in her sister's life.
Beatrice tells the reader the story of her life with and without her sister. As they grow, Tess becomes the bohemian artist and Beatrice the suited New York consultant. What drove them to the choices they made? Beatrice reflects on their life together and why she is so sure her sister would not commit suicide.
Beatrice begins to understand that there was so much about her sister's life that she never knew. When Beatrice learns that Tess was pregnant and undergoing experimental gene therapy for her cystic fibrosis fetus at the time she went missing, she tries to learn everything she can about the therapy and the major pharmacy company that is underwriting it.
But Tess has also complained about menacing phone calls in the days leading up to her disappearance. And who is the father and what is his role in the story? Although the police are sympathetic, unless Beatrice can find evidence of some wrong-doing, they are reluctant to investigate. So it is up to Beatrice to find out.
Sister is part mystery, psychological suspense novel, and medical thriller all rolled into one. There are twists and turns in this novel that keep it moving at a good pace. Book discussion groups that like mysteries that delve into family relationships are sure to like this one.